Molecular Connectivity Predefines Polypharmacology: Aliphatic Rings, Chirality, and sp3 Centers Enhance Target Selectivity

• Główni autorzy: Stefania Monteleone (Autor), Julian E. Fuchs (Autor), Klaus R. Liedl (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2017-08-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Dark chemical matter compounds are small molecules that have been recently identified as highly potent and selective hits. For this reason, they constitute a promising class of possible candidates in the process of drug discovery and raise the interest of the scientific community. To this purpose, W...