Understanding the Effect of Statins and Patient Adherence in Atherosclerosis via a Quantitative Systems Pharmacology Model Using a Novel, Hybrid, and Multi-Scale Approach

Background and Objective: Statins are one of the most prescribed drugs to treat atherosclerosis. They inhibit the hepatic HMG-CoA reductase, causing a reduction of circulating cholesterol and LDL levels. Statins have had undeniable success; however, the benefits of statin therapy crystallize only if...

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Glavni autori: Cesar Pichardo-Almarza (Autor), Vanessa Diaz-Zuccarini (Autor)
Format: Knjiga
Izdano: Frontiers Media S.A., 2017-09-01T00:00:00Z.
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