Deletion of Smooth Muscle Lethal Giant Larvae 1 Promotes Neointimal Hyperplasia in Mice

• Main Authors: Ya Zhang (Author), Peidong Yuan (Author), Xiaoping Ma (Author), Qiming Deng (Author), Jiangang Gao (Author), Jianmin Yang (Author), Tianran Zhang (Author), Cheng Zhang (Author), Wencheng Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vascular smooth muscle cell (VSMC) proliferation and migration contribute to neointimal hyperplasia after injury, which causes vascular remodeling related to arteriosclerosis, hypertension, and restenosis. Lethal giant larvae 1 (LGL1) is a highly conserved protein and plays an important role in cell...