ABCG2 is not able to catalyze glutathione efflux and does not contribute to GSH-dependent collateral sensitivity

• 主要な著者: Charlotte eGauthier (著者), Csilla eOzvegy-Laczka (著者), Gergely eSzakacs (著者), Balazs eSarkadi (著者), Attilio eDi Pietro (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2013-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

ABCG2 is a key human ATP-Binding Cassette (ABC) transporter mediating cancer cell chemoresistance. In the case of ABCC1, another multidrug transporter, earlier findings documented that certain modulators greatly increase ABCC1-mediated GSH efflux and, upon depletion of intracellular glutathione (GSH...