ABCG2 is not able to catalyze glutathione efflux and does not contribute to GSH-dependent collateral sensitivity

• Main Authors: Charlotte eGauthier (Author), Csilla eOzvegy-Laczka (Author), Gergely eSzakacs (Author), Balazs eSarkadi (Author), Attilio eDi Pietro (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABCG2 is a key human ATP-Binding Cassette (ABC) transporter mediating cancer cell chemoresistance. In the case of ABCC1, another multidrug transporter, earlier findings documented that certain modulators greatly increase ABCC1-mediated GSH efflux and, upon depletion of intracellular glutathione (GSH...