ABCG2 is not able to catalyze glutathione efflux and does not contribute to GSH-dependent collateral sensitivity

• Autori principali: Charlotte eGauthier (Autore), Csilla eOzvegy-Laczka (Autore), Gergely eSzakacs (Autore), Balazs eSarkadi (Autore), Attilio eDi Pietro (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2013-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

ABCG2 is a key human ATP-Binding Cassette (ABC) transporter mediating cancer cell chemoresistance. In the case of ABCC1, another multidrug transporter, earlier findings documented that certain modulators greatly increase ABCC1-mediated GSH efflux and, upon depletion of intracellular glutathione (GSH...