Process to Remove the Size Variants Contained in the Antibody-Chelator Complex PCTA-NCAB001 for Radiolabeling with Copper-64

• Main Authors: Yukie Yoshii (Author), Hiroki Matsumoto (Author), Chika Igarashi (Author), Tomoko Tachibana (Author), Fukiko Hihara (Author), Mitsuhiro Shinada (Author), Atsuo Waki (Author), Sei Yoshida (Author), Kenichiro Naito (Author), Kimiteru Ito (Author), Tatsuya Higashi (Author), Hiroaki Kurihara (Author), Makoto Ueno (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Understanding the physicochemical properties of antibody-drug conjugates is critical to assess their quality at manufacturing and monitor them during subsequent storage. For radiometal-antibody complexes, it is important to control the properties of the antibody-chelator conjugate to maintain the qu...