Mitigation of acetaminophen-induced liver toxicity by the novel phosphatidylinositol 3-kinase inhibitor alpelisib

The sterile inflammatory response mediated by Toll-like receptors (TLRs) 4 and 9 is implicated in the massive hepatic damage caused by acetaminophen (APAP)-overdose. There is a crosstalk between TLR-dependent signaling with other intracellular kinases like phosphatidylinositol 3-kinases (PI3Ks). Nev...

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Main Authors: Mohamed E. Shaker (Author), Hesham A. M. Gomaa (Author), Sara H. Hazem (Author), Mohamed A. Abdelgawad (Author), Mohamed El-Mesery (Author), Ahmed A. Shaaban (Author)
Format: Book
Published: Frontiers Media S.A., 2023-08-01T00:00:00Z.
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3rd Floor Main Library

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