Tricyclic Antidepressant Structure-Related Alterations in Calcium-Dependent Inhibition and Open-Channel Block of NMDA Receptors

N-methyl-D-aspartate receptors (NMDARs) are an essential target for the analgetic action of tricyclic antidepressants (TCAs). Their therapeutic blood concentrations achieve 0.5-1.5 μM, which, however, are insufficient to cause in vitro the open-channel block known as the only effect of TCAs on NMDAR...

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Main Authors: Yulia D. Stepanenko (Author), Dmitry A. Sibarov (Author), Natalia N. Shestakova (Author), Sergei M. Antonov (Author)
Format: Book
Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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