Inhibition of IKKβ by celastrol and its analogues - an in silico and in vitro approach

• Main Authors: Karpagam Veerappan (Author), Sathishkumar Natarajan (Author), Purushoth Ethiraj (Author), Umashankar Vetrivel (Author), Shila Samuel (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context: Alzheimer's disease (AD) is the most common form of dementia affecting the aged population and neuroinflammation is one of the most observed AD pathologies. NF-κB is the central regulator of inflammation and inhibitor κB kinase (IKK) is the converging point in NF-κB activation. Celastr...