Pharmacokinetic Disposition of Amiodarone When Given with an Intralipid Rescue Strategy

• Main Authors: Sean N. Avedissian (Author), Michelle Pham (Author), Medha D. Joshi (Author), Marc H. Scheetz (Author), Ashkan Salamatipour (Author), Jeffin M. Panickar (Author), Khrystyna Hlukhenka (Author), Cristina Miglis (Author), Athanasios Chalkias (Author), Theodoros Xanthos (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

While the antiarrhythmic drug amiodarone is commonly used in clinical practice, it has a narrow therapeutic index that can lead to acute overdose. One proposed method to deal with this toxicity is lipid emulsion therapy, which may potentially quench the free amiodarone in blood and prevent its furth...