Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery

• Main Authors: Wanling Liang (Author), Alan Y.L. Chan (Author), Michael Y.T. Chow (Author), Fiona F.K. Lo (Author), Yingshan Qiu (Author), Philip C.L. Kwok (Author), Jenny K.W. Lam (Author)
• Format: Book
• Published: Elsevier, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The therapeutic potential of small nucleic acids such as small interfering RNA (siRNA) to treat lung diseases has been successfully demonstrated in many in vivo studies. A major barrier to their clinical application is the lack of a safe and efficient inhaled formulation. In this study, spray freeze...