Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform

• Main Authors: Caitlin Lynch (Author), Ryan Margolis (Author), Jacob Niebler (Author), Jameson Travers (Author), Srilatha Sakamuru (Author), Tongan Zhao (Author), Carleen Klumpp-Thomas (Author), Ruili Huang (Author), Menghang Xia (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor with a well-established role in regulating drug metabolism and clearance. Recent studies have shown that PXR is involved in cell proliferation, apoptosis, immune response, and energy homeostasis. It is important to identify compounds...