Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform

• Hoofdauteurs: Caitlin Lynch (Auteur), Ryan Margolis (Auteur), Jacob Niebler (Auteur), Jameson Travers (Auteur), Srilatha Sakamuru (Auteur), Tongan Zhao (Auteur), Carleen Klumpp-Thomas (Auteur), Ruili Huang (Auteur), Menghang Xia (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor with a well-established role in regulating drug metabolism and clearance. Recent studies have shown that PXR is involved in cell proliferation, apoptosis, immune response, and energy homeostasis. It is important to identify compounds...