Antitumor effects of chemically modified miR-143 lipoplexes in a mouse model of pelvic colorectal cancer via myristoylated alanine-rich C kinase substrate downregulation

• Main Authors: Jun Arima (Author), Kohei Taniguchi (Author), Nobuhiko Sugito (Author), Kazuki Heishima (Author), Yoshihisa Tokumaru (Author), Yosuke Inomata (Author), Kazumasa Komura (Author), Tomohito Tanaka (Author), Masa-Aki Shibata (Author), Sang-Woong Lee (Author), Yukihiro Akao (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Replenishing tumor-suppressor miRNAs (TS-miRNAs) is a potential next-generation nucleic acid-based therapeutic approach. Establishing an effective miRNA delivery system is essential to successful TS-miRNA therapy. To overcome vulnerability to RNA nucleases, we previously developed a chemically modif...