Lactacystin-induced kidney fibrosis: Protection by melatonin and captopril

• Main Authors: Kristina Repova (Author), Peter Stanko (Author), Tomas Baka (Author), Kristina Krajcirovicova (Author), Silvia Aziriova (Author), Jaroslav Hrenak (Author), Andrej Barta (Author), Stefan Zorad (Author), Russel J. Reiter (Author), Michaela Adamcova (Author), Fedor Simko (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lactacystin is a specific proteasome inhibitor that blocks the hydrolysis of intracellular proteins by ubiquitin/proteasome system inhibition. The administration of lactacystin to rats induced hypertension and remodeling of the left ventricle and aorta. This study tested whether lactacystin induces...