Nested PCR and the TaqMan SNP Genotyping Assay enhanced the sensitivity of drug resistance testing of Mycobacterium leprae using clinical specimens of leprosy patients.

• Главные авторы: Xiaohua Chen (Автор), Jun He (Автор), Jian Liu (Автор), Yuangang You (Автор), Lianchao Yuan (Автор), Yan Wen (Автор)
• Формат: ‌
• Опубликовано: Public Library of Science (PLoS), 2019-12-01T00:00:00Z.
• Предметы: article
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BACKGROUND:Although leprosy is efficiently treated by multidrug therapy, resistance to first-line (dapsone, rifampin) and second-line (fluoroquinolones) drugs has been described worldwide. However, the characteristics of drug resistance in Southwest China remain unknown. Furthermore, the sensitivity...