Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII

• Main Authors: Ashraf K. El-Damasy (Author), Hyun Ji Kim (Author), Alessio Nocentini (Author), Seon Hee Seo (Author), Wagdy M. Eldehna (Author), Eun-Kyoung Bang (Author), Claudiu T. Supuran (Author), Gyochang Keum (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of 6-ureido/amidocoumarins (5a-p and 7a-c) has been designed and synthesised to develop potent and isoform- selective carbonic anhydrase hCA XI and XII inhibitors. All coumarin derivatives were investigated for their CA inhibitory effect against hCA I, II, IX, and XII. Interestingly, target...