Radiation induces long‐term muscle fibrosis and promotes a fibrotic phenotype in fibro‐adipogenic progenitors

• Main Authors: Nicolas Collao (Author), Donna D'Souza (Author), Laura Messeiller (Author), Evan Pilon (Author), Jessica Lloyd (Author), Jillian Larkin (Author), Matthew Ngu (Author), Alexanne Cuillerier (Author), Alexander E. Green (Author), Keir J. Menzies (Author), Yan Burelle (Author), Michael De Lisio (Author)
• Format: Book
• Published: Wiley, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Radiation‐induced muscle pathology, characterized by muscle atrophy and fibrotic tissue accumulation, is the most common debilitating late effect of therapeutic radiation exposure particularly in juvenile cancer survivors. In healthy muscle, fibro/adipogenic progenitors (FAPs) ar...