Double-stranded RNA induction asa potential dynamic biomarkerfor DNA-demethylating agents

• Main Authors: Minjeong Kang (Author), Raisa Kharbash (Author), Ja Min Byun (Author), Jaemin Jeon (Author), Ahsan Ausaf Ali (Author), Doyeong Ku (Author), Jimin Yoon (Author), Yongsuk Ku (Author), Jooyeon Sohn (Author), Seung-Jae V. Lee (Author), Dong-Yeop Shin (Author), Youngil Koh (Author), Sung-Soo Yoon (Author), Junshik Hong (Author), Yoosik Kim (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypomethylating agents (HMAs), such as azacitidine and decitabine, induce cancer cell death by demethylating DNAs to promote the expression of tumor-suppressor genes. HMAs also reactivate the transcription of endogenous double-stranded RNAs (dsRNAs) that trigger the innate immune response and subseq...