Design and synthesis of tricyclic terpenoid derivatives as novel PTP1B inhibitors with improved pharmacological property and in vivo antihyperglycaemic efficacy

• Main Authors: Lingling Yang (Author), Feng Chen (Author), Cheng Gao (Author), Jiabao Chen (Author), Junyan Li (Author), Siyan Liu (Author), Yuanyuan Zhang (Author), Zhouyu Wang (Author), Shan Qian (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Overexpression of protein tyrosine phosphatase 1B (PTP1B) induces insulin resistance in various basic and clinical research. In our previous work, a synthetic oleanolic acid (OA) derivative C10a with PTP1B inhibitory activity has been reported. However, C10a has some pharmacological defects and cyto...