Quasi-Irreversible Inhibition of CYP2D6 by Berberine

• Main Authors: Ha Gyeong Kim (Author), Han Sol Lee (Author), Jang Su Jeon (Author), Young Jae Choi (Author), Yeon Jung Choi (Author), So-Yeol Yoo (Author), Eun-yeong Kim (Author), Kiho Lee (Author), InWha Park (Author), MinKyun Na (Author), Han-Jin Park (Author), Seung-Woo Cho (Author), Jong-Hoon Kim (Author), Jae-Young Lee (Author), Sang Kyum Kim (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In our previous study, Hwang-Ryun-Hae-Dok-Tang, which contains berberine (BBR) as a main active ingredient, inhibited cytochrome P450 (CYP) 2D6 in a quasi-irreversible manner. However, no information is available on the detailed mechanism of BBR-induced CYP2D6 inhibition. Thus, the present study aim...