Quasi-Irreversible Inhibition of CYP2D6 by Berberine

• Главные авторы: Ha Gyeong Kim (Автор), Han Sol Lee (Автор), Jang Su Jeon (Автор), Young Jae Choi (Автор), Yeon Jung Choi (Автор), So-Yeol Yoo (Автор), Eun-yeong Kim (Автор), Kiho Lee (Автор), InWha Park (Автор), MinKyun Na (Автор), Han-Jin Park (Автор), Seung-Woo Cho (Автор), Jong-Hoon Kim (Автор), Jae-Young Lee (Автор), Sang Kyum Kim (Автор)
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• Опубликовано: MDPI AG, 2020-09-01T00:00:00Z.
• Предметы: article
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In our previous study, Hwang-Ryun-Hae-Dok-Tang, which contains berberine (BBR) as a main active ingredient, inhibited cytochrome P450 (CYP) 2D6 in a quasi-irreversible manner. However, no information is available on the detailed mechanism of BBR-induced CYP2D6 inhibition. Thus, the present study aim...