Whole genome sequence analysis of Salmonella Typhi provides evidence of phylogenetic linkage between cases of typhoid fever in Santiago, Chile in the 1980s and 2010-2016.

• Main Authors: Mailis Maes (Author), Michael J Sikorski (Author), Megan E Carey (Author), Ellen E Higginson (Author), Zoe A Dyson (Author), Alda Fernandez (Author), Pamela Araya (Author), Sharon M Tennant (Author), Stephen Baker (Author), Rosanna Lagos (Author), Juan Carlos Hormazábal (Author), Myron M Levine (Author), Gordon Dougan (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Typhoid fever epidemiology was investigated rigorously in Santiago, Chile during the 1980s, when Salmonella enterica serovar Typhi (S. Typhi) caused seasonal, hyperendemic disease. Targeted interventions reduced the annual typhoid incidence rates from 128-220 cases/105 population occurring between 1...