Molecular characterisation of sickle cell disease and classification of major haplotypes associated with the β-globin cluster (HBB gene) by means of SNP marker sequencing in a group of samples from Bolívar, Colombia

• Main Authors: Marcela Díaz-Matallana (Author), Ignacio Briceño (Author), Escilda Benavides-Benítez (Author), Jaime E. Bernal (Author), Julio C. Martínez-Lozano (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractBackground Colombia has a mestizo population and the prevalence of haemoglobin variants varies according to each region, but heterozygous carriers can be found in all of them.Aim To characterise sickle cell disease (SCD) haematologically, biochemically, and molecularly, and detect classic ha...