Gastric inhibitory polypeptide receptor antagonism suppresses intramuscular adipose tissue accumulation and ameliorates sarcopenia

• Main Authors: Yuya Takahashi (Author), Hiroki Fujita (Author), Yusuke Seino (Author), Satoko Hattori (Author), Shihomi Hidaka (Author), Tsuyoshi Miyakawa (Author), Atsushi Suzuki (Author), Hironori Waki (Author), Daisuke Yabe (Author), Yutaka Seino (Author), Yuichiro Yamada (Author)
• Format: Book
• Published: Wiley, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Intramuscular adipose tissue (IMAT) formation derived from muscle fibro‐adipogenic progenitors (FAPs) has been recognized as a pathological feature of sarcopenia. This study aimed to explore whether genetic and pharmacological gastric inhibitory polypeptide (GIP) receptor antagon...