Development of [131I]I-EOE-TPZ and [131I]I-EOE-TPZMO: Novel Tirapazamine (TPZ)-Based Radioiodinated Pharmaceuticals for Application in Theranostic Management of Hypoxia

• Huvudskapare: Hassan Elsaidi (Författare, medförfattare), Fatemeh Ahmadi (Författare, medförfattare), Leonard I. Wiebe (Författare, medförfattare), Piyush Kumar (Författare, medförfattare)
• Materialtyp: Bok
• Publicerad: MDPI AG, 2019-01-01T00:00:00Z.
• Ämnen: article
• Länkar: Connect to this object online.

Introduction: Benzotriazine-1,4-dioxides (BTDOs) such as tirapazamine (TPZ) and its derivatives act as radiosensitizers of hypoxic tissues. The benzotriazine-1-monoxide (BTMO) metabolite (SR 4317, TPZMO) of TPZ also has radiosensitizing properties, and via unknown mechanisms, is a potent enhancer of...