The challenges and opportunities of αvβ3-based therapeutics in cancer: From bench to clinical trials

• Main Authors: Yanlun Gu (Author), Bingqi Dong (Author), Xu He (Author), Zhiwei Qiu (Author), Juqi Zhang (Author), Mo Zhang (Author), Haitao Liu (Author), Xiaocong Pang (Author), Yimin Cui (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Integrins are main cell adhesion receptors serving as linker attaching cells to extracellular matrix (ECM) and bidirectional hubs transmitting biochemical and mechanical signals between cells and their environment. Integrin αvβ3 is a critical family member of integrins and interacts with ECM protein...