Transferrin Non-Viral Gene Therapy for Treatment of Retinal Degeneration

• Главные авторы: Karine Bigot (Автор), Pauline Gondouin (Автор), Romain Bénard (Автор), Pierrick Montagne (Автор), Jenny Youale (Автор), Marie Piazza (Автор), Emilie Picard (Автор), Thierry Bordet (Автор), Francine Behar-Cohen (Автор)
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• Опубликовано: MDPI AG, 2020-09-01T00:00:00Z.
• Предметы: article
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Dysregulation of iron metabolism is observed in animal models of retinitis pigmentosa (RP) and in patients with age-related macular degeneration (AMD), possibly contributing to oxidative damage of the retina. Transferrin (TF), an endogenous iron chelator, was proposed as a therapeutic candidate. Her...