Transferrin Non-Viral Gene Therapy for Treatment of Retinal Degeneration

• Main Authors: Karine Bigot (Author), Pauline Gondouin (Author), Romain Bénard (Author), Pierrick Montagne (Author), Jenny Youale (Author), Marie Piazza (Author), Emilie Picard (Author), Thierry Bordet (Author), Francine Behar-Cohen (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dysregulation of iron metabolism is observed in animal models of retinitis pigmentosa (RP) and in patients with age-related macular degeneration (AMD), possibly contributing to oxidative damage of the retina. Transferrin (TF), an endogenous iron chelator, was proposed as a therapeutic candidate. Her...