Transferrin Non-Viral Gene Therapy for Treatment of Retinal Degeneration

• Hoofdauteurs: Karine Bigot (Auteur), Pauline Gondouin (Auteur), Romain Bénard (Auteur), Pierrick Montagne (Auteur), Jenny Youale (Auteur), Marie Piazza (Auteur), Emilie Picard (Auteur), Thierry Bordet (Auteur), Francine Behar-Cohen (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2020-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Dysregulation of iron metabolism is observed in animal models of retinitis pigmentosa (RP) and in patients with age-related macular degeneration (AMD), possibly contributing to oxidative damage of the retina. Transferrin (TF), an endogenous iron chelator, was proposed as a therapeutic candidate. Her...