Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease
Polycystic kidney disease (PKD) is characterized by slow expansion of fluid-filled cysts derived from tubules within the kidney. Cystic expansion results in injury to surrounding parenchyma and leads to inflammation, scarring and ultimately loss of renal function. Macrophages are a key element in th...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
The Company of Biologists,
2016-09-01T00:00:00Z.
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