Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease

• Главные авторы: Jacqueline D. Peda (Автор), Sally M. Salah (Автор), Darren P. Wallace (Автор), Patrick E. Fields (Автор), Connor J. Grantham (Автор), Timothy A. Fields (Автор), Katherine I. Swenson-Fields (Автор)
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• Опубликовано: The Company of Biologists, 2016-09-01T00:00:00Z.
• Предметы: article
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Polycystic kidney disease (PKD) is characterized by slow expansion of fluid-filled cysts derived from tubules within the kidney. Cystic expansion results in injury to surrounding parenchyma and leads to inflammation, scarring and ultimately loss of renal function. Macrophages are a key element in th...