Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease

• Main Authors: Jacqueline D. Peda (Author), Sally M. Salah (Author), Darren P. Wallace (Author), Patrick E. Fields (Author), Connor J. Grantham (Author), Timothy A. Fields (Author), Katherine I. Swenson-Fields (Author)
• Format: Book
• Published: The Company of Biologists, 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polycystic kidney disease (PKD) is characterized by slow expansion of fluid-filled cysts derived from tubules within the kidney. Cystic expansion results in injury to surrounding parenchyma and leads to inflammation, scarring and ultimately loss of renal function. Macrophages are a key element in th...