Sulphonamide inhibition studies of the β-carbonic anhydrase GsaCAβ present in the salmon platyhelminth parasite Gyrodactylus salaris

• Main Authors: Ashok Aspatwar (Author), Alessandro Bonardi (Author), Heidi Aisala (Author), Ksenia Zueva (Author), Craig R Primmer (Author), Jaakko Lumme (Author), Seppo Parkkila (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A β-class carbonic anhydrase (CA, EC 4.2.1.1) present in the genome of the Monogenean platyhelminth Gyrodactylus salaris, a fish parasite, GsaCAβ, has been investigated for its inhibitory effects with a panel of sulphonamides and sulfamates, some of which in clinical use. Several effective GsaCAβ in...