Protective Effect of Knee Postoperative Fluid on Oxidative-Induced Damage in Human Knee Articular Chondrocytes

• Main Authors: Roberta Giordo (Author), Smitha Tulasigeri Totiger (Author), Gianfilippo Caggiari (Author), Annalisa Cossu (Author), Andrea Fabio Manunta (Author), Anna Maria Posadino (Author), Gianfranco Pintus (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The oxidative-stress-elicited deterioration of chondrocyte function is the initial stage of changes leading to the disruption of cartilage homeostasis. These changes entail a series of catabolic damages mediated by proinflammatory cytokines, MMPs, and aggrecanases, which increase ROS generation. Suc...