A New Quinone-Based Inhibitor of Mitochondrial Complex I in D-Conformation, Producing Invasion Reduction and Sensitization to Venetoclax in Breast Cancer Cells

A New Quinone-Based Inhibitor of Mitochondrial Complex I in D-Conformation, Producing Invasion Reduction and Sensitization to Venetoclax in Breast Cancer Cells

Mitochondrial Complex I plays a crucial role in the proliferation, chemoresistance, and metastasis of breast cancer (BC) cells. This highlights it as an attractive target for anti-cancer drugs. Using submitochondrial particles, we identified FRV-1, an <i>ortho</i>-carbonyl quinone, which...

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Main Authors: Matías Monroy-Cárdenas (Author), Víctor Andrades (Author), Cristopher Almarza (Author), María Jesús Vera (Author), Jorge Martínez (Author), Rodrigo Pulgar (Author), John Amalraj (Author), Ramiro Araya-Maturana (Author), Félix A. Urra (Author)
Format: Book
Published: MDPI AG, 2023-08-01T00:00:00Z.
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