Effect of Astragali radix extract on pharmacokinetic behavior of dapagliflozin in healthy and type 2 diabetic rats

• Main Authors: Wandi Du (Author), Jiarong Hu (Author), Jingru Liang (Author), Xiaolei Yang (Author), Boyu Fang (Author), Guo Ma (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: This study aimed to investigate effect of antidiabetic herb Astragali Radix (AR) on pharmacokinetic behavior of dapagliflozin (DAPA) in healthy rats and type 2 diabetes mellitus (T2DM) rats.Methods: The T2DM rats were induced by high-fat diet (HFD) and intraperitoneal injection of strepto...