An innovative phase I study in healthy subjects to determine the mass balance, elimination, metabolism, and absolute bioavailability of mitapivat

Abstract Mitapivat, a first‐in‐class, oral, small‐molecule, allosteric activator of the red blood cell‐specific form of pyruvate kinase (PKR), was approved for the treatment of hemolytic anemia in adults with pyruvate kinase (PK) deficiency. In this phase I mass balance study in healthy males, we ad...

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Main Authors: Chandra Prakash (Author), Heidi Mangus (Author), Yan Yan (Author), Hua Yang (Author), Varsha Iyer (Author)
Format: Book
Published: Wiley, 2023-10-01T00:00:00Z.
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