Humoral and cellular immune responses to Yersinia pestis Pla antigen in humans immunized with live plague vaccine.

• Main Authors: Valentina A Feodorova (Author), Anna M Lyapina (Author), Maria A Khizhnyakova (Author), Sergey S Zaitsev (Author), Lidiya V Sayapina (Author), Tatiana E Arseneva (Author), Alexey L Trukhachev (Author), Svetlana A Lebedeva (Author), Maxim V Telepnev (Author), Onega V Ulianova (Author), Elena P Lyapina (Author), Sergey S Ulyanov (Author), Vladimir L Motin (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To establish correlates of human immunity to the live plague vaccine (LPV), we analyzed parameters of cellular and antibody response to the plasminogen activator Pla of Y. pestis. This outer membrane protease is an essential virulence factor that is steadily expressed by Y. pestis.PBMCs and sera wer...