Inhibition of the skeletal muscle Lands cycle ameliorates weakness induced by physical inactivity

• Main Authors: Justin L. Shahtout (Author), Hiroaki Eshima (Author), Patrick J. Ferrara (Author), J. Alan Maschek (Author), James E. Cox (Author), Micah J. Drummond (Author), Katsuhiko Funai (Author)
• Format: Book
• Published: Wiley, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Lipid hydroperoxides (LOOH) have been implicated in skeletal muscle atrophy with age and disuse. Lysophosphatidylcholine acyltransferase 3 (LPCAT3), an enzyme of the Lands cycle, conjugates a polyunsaturated fatty acyl chain to a lysophospholipid to form a polyunsaturated fatty a...