CVM-1118 (foslinanib), a 2-phenyl-4-quinolone derivative, promotes apoptosis and inhibits vasculogenic mimicry via targeting TRAP1

• मुख्य लेखकों: Lifen Shen (लेखक), Yen-Ling Chen (लेखक), Chu-Chun Huang (लेखक), Yu-Chiau Shyu (लेखक), Richard E. B. Seftor (लेखक), Elisabeth A. Seftor (लेखक), Mary J. C. Hendrix (लेखक), Du-Shieng Chien (लेखक), Yi-Wen Chu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

CVM-1118 (foslinanib) is a phosphoric ester compound selected from 2-phenyl-4-quinolone derivatives. The NCI 60 cancer panel screening showed CVM-1125, the major active metabolite of CVM-1118, to exhibit growth inhibitory and cytotoxic effects at nanomolar range. CVM-1118 possesses multiple bioactiv...