Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni.

• Main Authors: Cristiana Lalli (Author), Alessandra Guidi (Author), Nadia Gennari (Author), Sergio Altamura (Author), Alberto Bresciani (Author), Giovina Ruberti (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schistosomiasis, one of the world's greatest neglected tropical diseases, is responsible for over 280,000 human deaths per annum. Praziquantel, developed in the 1970s, has high efficacy, excellent tolerability, few and transient side effects, simple administration procedures and competitive cos...