Discovery of new 3-methylquinoxalines as potential anti-cancer agents and apoptosis inducers targeting VEGFR-2: design, synthesis, and in silico studies

• Main Authors: Mohammed M. Alanazi (Author), Alaa Elwan (Author), Nawaf A. Alsaif (Author), Ahmad J. Obaidullah (Author), Hamad M. Alkahtani (Author), Abdulrahman A. Al-Mehizia (Author), Sultan M. Alsubaie (Author), Mohammed S. Taghour (Author), Ibrahim H. Eissa (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is an urgent need to design new anticancer agents that can prevent cancer cell proliferation even with minimal side effects. Accordingly, two new series of 3-methylquinoxalin-2(1H)-one and 3-methylquinoxaline-2-thiol derivatives were designed to act as VEGFR-2 inhibitors. The designed derivati...