Clinical Pharmacology of Midazolam in Neonates and Children: Effect of Disease-A Review
Midazolam is a benzodiazepine with rapid onset of action and short duration of effect. In healthy neonates the half-life (t1/2) and the clearance (Cl) are 3.3-fold longer and 3.7-fold smaller, respectively, than in adults. The volume of distribution (Vd) is 1.1 L/kg both in neonates and adults. Mida...
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Hindawi Limited,
2014-01-01T00:00:00Z.
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