The SDHB Arg230His mutation causing familial paraganglioma alters glycolysis in a new Caenorhabditis elegans model

• Main Authors: Éva Saskői (Author), Zoltán Hujber (Author), Gábor Nyírő (Author), István Likó (Author), Barbara Mátyási (Author), Gábor Petővári (Author), Katalin Mészáros (Author), Attila L. Kovács (Author), László Patthy (Author), Shreyas Supekar (Author), Hao Fan (Author), Gergely Sváb (Author), László Tretter (Author), Arunabh Sarkar (Author), Aamir Nazir (Author), Anna Sebestyén (Author), Attila Patócs (Author), Anil Mehta (Author), Krisztina Takács-Vellai (Author)
• Format: Book
• Published: The Company of Biologists, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The conserved B-subunit of succinate dehydrogenase (SDH) participates in the tricarboxylic acid cycle (TCA) cycle and mitochondrial electron transport. The Arg230His mutation in SDHB causes heritable pheochromocytoma/paraganglioma (PPGL). In Caenorhabditis elegans, we generated an in vivo PPGL model...