Synthesis of new para-aminobenzoic acid derivatives, in vitro biological evaluation and preclinical validation of DAB-2-28 as a therapeutic option for the treatment of bladder cancer

• Main Authors: Yassine Oufqir (Author), Laurie Fortin (Author), Julie Girouard (Author), Francis Cloutier (Author), Maude Cloutier (Author), Marie-France Leclerc (Author), Denise Belgorosky (Author), Ana María Eiján (Author), Gervais Bérubé (Author), Carlos Reyes-Moreno (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic inflammation plays a crucial role in bladder cancer (BCa) development and progression. To offer a unique treatment opportunity for this type of cancer, a hydrazide derivative namely, DAB-1, was recently identified in our laboratory as a potential drug to target cancer-related inflammation. I...