The Influence of Pressure on the Intrinsic Dissolution Rate of Amorphous Indomethacin

• Autori principali: Korbinian Löbmann (Autore), Konstantina Flouda (Autore), Danwen Qiu (Autore), Theodosia Tsolakou (Autore), Wenbo Wang (Autore), Thomas Rades (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2014-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

New drug candidates increasingly tend to be poorly water soluble. One approach to increase their solubility is to convert the crystalline form of a drug into the amorphous form. Intrinsic dissolution testing is an efficient standard method to determine the intrinsic dissolution rate (IDR) of a drug...