Metformin Mitigates Fibrosis and Glucose Intolerance Induced by Doxorubicin in Subcutaneous Adipose Tissue

• Main Authors: Luana A. Biondo (Author), Helena A. Batatinha (Author), Camila O. Souza (Author), Alexandre A. S. Teixeira (Author), Loreana S. Silveira (Author), Maria I. Alonso-Vale (Author), Lila M. Oyama (Author), Michele J. Alves (Author), Marilia Seelaender (Author), José C. R. Neto (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Doxorubicin (DX) is a chemotherapeutic drug that is used in clinical practice that promotes deleterious side effects in non-tumor tissues such as adipose tissue. We showed that DX leads to extensive damage in adipose tissue via a disruption in 5'-adenosine monophosphate-activated protein kinase...