Defining a murine ovarian cancer model for the evaluation of conditionally-replicative adenovirus (CRAd) virotherapy agents

• Main Authors: Rebeca González-Pastor (Author), Ahmad Mohammad Ashshi (Author), Adel Galal El-Shemi (Author), Igor P. Dmitriev (Author), Elena A. Kashentseva (Author), Zhi Hong Lu (Author), S. Peter Goedegebuure (Author), Osvaldo L. Podhajcer (Author), David T. Curiel (Author)
• Format: Book
• Published: BMC, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Virotherapy represents a promising approach for ovarian cancer. In this regard, conditionally replicative adenovirus (CRAd) has been translated to the context of human clinical trials. Advanced design of CRAds has sought to exploit their capacity to induce anti-tumor immunization...