A phase two randomised controlled double blind trial of high dose intravenous methylprednisolone and oral prednisolone versus intravenous normal saline and oral prednisolone in individuals with leprosy type 1 reactions and/or nerve function impairment.

• Hauptverfasser: Stephen L Walker (Verfasst von), Peter G Nicholls (Verfasst von), Sushmita Dhakal (Verfasst von), Rachel A Hawksworth (Verfasst von), Murdo Macdonald (Verfasst von), Kishori Mahat (Verfasst von), Shudan Ruchal (Verfasst von), Sushma Hamal (Verfasst von), Deanna A Hagge (Verfasst von), Kapil D Neupane (Verfasst von), Diana N J Lockwood (Verfasst von)
• Format: Buch
• Veröffentlicht: Public Library of Science (PLoS), 2011-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

BACKGROUND: Leprosy Type 1 reactions are a major cause of nerve damage and the preventable disability that results. Type 1 reactions are treated with oral corticosteroids and there are few data to support the optimal dose and duration of treatment. Type 1 reactions have a Th1 immune profile: cells i...