A phase two randomised controlled double blind trial of high dose intravenous methylprednisolone and oral prednisolone versus intravenous normal saline and oral prednisolone in individuals with leprosy type 1 reactions and/or nerve function impairment.

• Main Authors: Stephen L Walker (Author), Peter G Nicholls (Author), Sushmita Dhakal (Author), Rachel A Hawksworth (Author), Murdo Macdonald (Author), Kishori Mahat (Author), Shudan Ruchal (Author), Sushma Hamal (Author), Deanna A Hagge (Author), Kapil D Neupane (Author), Diana N J Lockwood (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Leprosy Type 1 reactions are a major cause of nerve damage and the preventable disability that results. Type 1 reactions are treated with oral corticosteroids and there are few data to support the optimal dose and duration of treatment. Type 1 reactions have a Th1 immune profile: cells i...