Oxytocin Protects Against Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting PI3K/AKT Pathway via a lncRNA GAS5/miR-375-3p/KLF4-Dependent Mechanism

• Main Authors: Yuqiao Yang (Author), Zhuoran Wang (Author), Mengran Yao (Author), Wei Xiong (Author), Jun Wang (Author), Yu Fang (Author), Wei Yang (Author), Haixia Jiang (Author), Ning Song (Author), Lan Liu (Author), Jinqiao Qian (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cardiac hypertrophy is caused by cardiac volume or pressure overload conditions and ultimately leads to contractile dysfunction and heart failure. Oxytocin (OT), an endocrine nonapeptide, has been identified as a cardiovascular homeostatic hormone with anti-hypertrophic effects. However, the underly...