Adverse Effects of Methylglyoxal on Transcriptome and Metabolic Changes in Visceral Adipose Tissue in a Prediabetic Rat Model

• Main Authors: Martina Hüttl (Author), Irena Markova (Author), Denisa Miklankova (Author), Pavol Makovicky (Author), Terezie Pelikanova (Author), Ondrej Šeda (Author), Lucie Šedová (Author), Hana Malinska (Author)
• Format: Book
• Published: MDPI AG, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Excessive methylglyoxal (MG) production contributes to metabolic and vascular changes by increasing inflammatory processes, disturbing regulatory mechanisms and exacerbating tissue dysfunction. MG accumulation in adipocytes leads to structural and functional changes. We used transcriptome analysis t...