Dictyostelium Differentiation-Inducing Factor-1 Binds to Mitochondrial Malate Dehydrogenase and Inhibits Its Activity

• Main Authors: Tomoko Matsuda (Author), Fumi Takahashi-Yanaga (Author), Tatsuya Yoshihara (Author), Katsumi Maenaka (Author), Yutaka Watanabe (Author), Yoshikazu Miwa (Author), Sachio Morimoto (Author), Yuzuru Kubohara (Author), Masato Hirata (Author), Toshiyuki Sasaguri (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have reported that the differentiation-inducing factors (DIFs) DIF-1 and DIF-3, morphogens secreted from Dictyostelium discoideum, inhibit proliferation of several cancer cells via suppression of the Wnt/ β-catenin signaling pathway. However, the target molecules of DIFs involved in the anti-prol...