Targeted degradation of LRG1 to attenuate renal fibrosis

• Main Authors: Linyao Fan (Author), Yingqiu Qi (Author), Xi Yang (Author), Yarui Xu (Author), Yana Zhang (Author), Longdi Wang (Author), Anying Zhu (Author), Lirong Zhang (Author), Jian Song (Author), Shengnan Du (Author), Guangjun Nie (Author), Huan Min (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leucine-rich α-2 glycoprotein 1 (LRG1), a secreted glycoprotein, has been identified as significantly upregulated in renal fibrosis, potentially exacerbating the condition by enhancing TGF-β-Smad3-dependent signaling pathways. Herein, utilizing our developed LRG1-targeting peptide for LRG1 recruitme...